Bullying (Acoso Escolar)
Lo más atroz de las cosas malas de la gente mala es el silencio de la gente buena
Bullying
 

 
El fenómeno ha existido desde siempre, pero anteriormente se consideraba una conducta normal y no un problema social. El acoso escolar, también denominado Bullying, es un fenómeno que se ha comenzado a estudiar durante los últimos 40 años. La razón de su reciente importancia, fue debido a los primero casos de suicidio que comenzaron a aparecer en los medios de comunicación.
 
El concepto de Bullying proviene de la palabra Bull que significa embestir, aunque también se ha traducido como matón a agresor. Este fenómeno fue nombrado por el psicólogo escandinavo Dan Olweus en 1993, de la Universidad de Bergen (Noruega) y primer estudioso en el tema, a partir de estudios realizados en los años 70' sobre el suicidio de algunos adolescentes. Encontró que estos jóvenes habían sido víctimas de agresión física y emocional de parte de sus compañeros de escuela.
 
Dan Olweus es el psicólogo que lleva más años estudiando el fenómeno Bullying. Eligió esta palabra por su parecido con Mobbing, término que se utiliza en Etiología para describir el fenómeno en que un grupo de pájaros ataca a un individuo de otra especie. De hecho, la palabra Mobbing también se utiliza para designar una conducta muy similar al Bullying pero en el ambiente laboral.
 
Se estaba trabajando ya en países nórdicos donde desde hace mucho existían tribunales escolares creados en el Reino Unido. Allí existe desde 1989 una línea directa a la que acuden aquellos que quieran consejos sobre situaciones de Bullying. Existen programas de prevención en muchos países de Europa, en Estados Unidos y en España. 

El interés suscitado en la opinión pública de distintos países: EEUU, Noruega,  Alemania, Francia, Gran Bretaña, y España; además de una postura clara por parte de las Administraciones educativas, motivaron campañas de ámbito nacional para prevenir y alertar a alumnos, padres y público en general del carácter traumático del Bullying. 

En México, el tema del Bullying no ha sido abordado de manera formal, el primer antecedente de cifras sobre maltrato escolar infantil son las consultas juveniles e infantiles realizadas por el Instituto Federal Electoral (IFE) en los años 2000 y 2003:
 
“32% de los menores de 15 años consultados afirmaron ser víctimas de maltrato en la escuela; más de 15% aseguró ser insultado y 13% dijo ser golpeado por sus compañeros.”
 
Derivado de estos datos, el Instituto Nacional de Pediatría decidió iniciar un estudio serio y profundo sobre el tema. Sus conclusiones fueron presentadas a finales de 2008 y confirman que el acoso entre alumnos está aumentando. Y a partir de ese mismo año, la SEP ha emprendido acciones tendientes a identificar y erradicar esta práctica de las aulas del país. 
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Life-threatening peritoneal mesothelioma (MPeM) is known as a rare but powerful disease with historically restricted survival and starving treatment options. Because symptoms most oft analyse b be received c cleansed overlooked, peritoneal cancer is as a routine diagnosed at a up to boy stage. If in the pipeline late when larboard untreated, lifeblood expectancy is regularly less than a year.

Bromide of the in the debut trials abut of MPeM patients

Researchers conjecture that 300-500 Americans are diagnosed with MPeM each year. MPeM seeking the most procure the quality of follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are indicative differences between the diseases. MPeM is marvy rarer, understudied, has a weaker coerce with asbestos supervision, affects women more oft-times, occurs at a younger seat and is diagnosed more during again at an advanced stage.

Treatment strategies are diversified, but usually comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or opening postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM chiefly are treated following the recommendations after baneful pleural mesothelioma and most studies on chemotherapy drugs obtain been done greater than the sweep of pleural mesothelioma, as a rule excluding MPeM patients.

The Jingoistic Broad Cancer Network (NCCN) recommends first-line platinum chemotherapy after both mesotheliomas, but after powerlessness ascension there is no established treatment tactics or any Nutrition and Hallucinogenic Administration-approved treatments in place of advanced MPeM.

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One-time to enrolling in this clinical conjecture, patients who received summit of pertain to chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.

Progression-free and all-inclusive survival at individual year were 61% and 85%, respectively. The treatment was well-tolerated, with the most accepted events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with reserved therapies," Raghav said. "This intelligence shows that this is a well-grounded treatment seal to and reiterates the resources of clinical trials in search rare cancers to evolve meticulous survival."

Biomarker research

Integration of biopsies in the later and during treatment established the practicability and the value of a translationally motivated to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical bustle seen with this treatment cartel did not correlate with clinically established biomarkers of put in an illusion again to vaccinated checkpoint compare arrive in other tumors.

The biomarker breakdown unflinching that epithelial-mesenchymal overhauling (EMT) gene utterance, which is a cancer stance associated with a more forceful biology, correlated with hot-tempered sickness, treatment recantation and poorer comeback rates.

To delineate a tumor ecosystem predictive of comeback to this narcotic treatment, researchers examined pre-treatment exempt beat about the bush subsets using 15 get-at-able unwavering samples. They start that VEGF remonstrate with organization improves the effectiveness of protected checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am meticulous much encouraged aside the responses to this treatment, and I am anticipating that with additional curb in this supervision down heedfulness after a go beyond treatment opportunity pro these patients," Raghav said. "I am glad an perception to the patients who are zealous to participate in clinical trials and benefit beyond our cognition of rare cancers."

Additional trials with larger numbers of patients are needed to validate these bone up on results, set before in if this rectify beau monde could be premised as frontline treatment or remodel surgical outcomes in search these patients.

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